Oxygen permeability of phosphatidylcholine--cholesterol membranes.
نویسندگان
چکیده
منابع مشابه
Biophysics Oxygen permeability of phosphatidylcholine - cholesterol membranes ( pulse ESR / permeability coefficient / oxygen transport ) WITOLD
Oxygen transport in phosphatidylcholinecholesterol membranes has been studied by observing the collision of molecular oxygen with nitroxide radical spin labels placed at various distances from the membrane surface using long-pulse saturation recovery ESR techniques. The collision rate was estimated for tempocholine phosphatidic acid ester, 5-doxylstearic acid, and 16-doxylstearic acid from spin...
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H+/OH- permeation through lipid bilayers occurs at anomalously high rates and the determinants of proton flux through membranes are poorly understood. Since all life depends on proton gradients, it is important to develop a greater understanding of proton leak phenomena. We have used stopped-flow fluorimetry to probe the influence of two lipid raft components, chol (cholesterol) and SM (sphingo...
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Aberrations in cholesterol homeostasis are associated with several diseases that can be linked to changes in cellular oxygen usage. Prior biological and physical studies have suggested that membrane cholesterol content can modulate oxygen delivery, but questions of magnitude and biological significance remain open for further investigation. Here, we use molecular dynamics simulations in a first...
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Mixed matrix membranes (MMMs) are attracting significant interest for pervaporation and gas separation applications. To better comprehend the impact of filler particles within polymer matrices, the species permeation mass transport was theoretically studied by numerical simulation using finite differences. The Fick’s second law of diffusion was solved for a three-dimensional MMM to obtain the c...
متن کاملOrganization and interaction of cholesterol and phosphatidylcholine in model bilayer membranes.
The molecular organization of sterols in liposomes of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) at 37 degrees C is examined by utilizing the fluorescent analogue of cholesterol cholesta-5,7,9-trien-3 beta-ol (cholestatrienol). (1) Cholestatrienol is shown to be indistinguishable from native cholesterol in terms of its ability to condense POPC, as determined by (i) pressure/area st...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1989
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.86.12.4474